It is now summer in the Parker family; and the usual amount of numerous events are happening in their separate lives. Ralphie is searching for the perfect top to use to beat the school bully with, the Old Man is in battle with their hillbilly neighbors, the Bumpus, while eagerly awaiting the discovery of the perfect fishing spot, and the Mother is attempting to collect all of the pieces of a glass china set at a local movie theater.

Perfume creator Satin Chau is about to reveal her new designer scent, 'Puppy,' when she is cruelly struck down by a rare condition called anosmia, which robs her of her sense of smell and could even kill her. With time fast running out, she begins a frantic search for the only people who can provide the tissue-donations she desperately needs: her long-lost sisters, Corduroy and Velour.