The madcap life of eccentric Mame Dennis and her bohemian, intellectual arty clique is disrupted when her deceased brother's 10-year-old son Patrick is entrusted to her care. Rather than bow to convention, Mame introduces the boy to her free-wheeling lifestyle, instilling in him her favorite credo, "Life is a banquet, and most poor sons of bitches are starving to death."

A town—where everyone seems to be named Johnson—stands in the way of the railroad. In order to grab their land, robber baron Hedley Lamarr sends his henchmen to make life in the town unbearable. After the sheriff is killed, the town demands a new sheriff from the Governor, so Hedley convinces him to send the town the first black sheriff in the west.

Mitzi Gaynor opens her second special with a dazzling performance of "Let Go." Additional songs include "Poor Papa," and "What'll I Do." She welcomes guest star Ross Martin (The Wild, Wild, West) for a musical-comedy spoof of Gone with the Wind. Other comedy skits include Mitzi as "The Kid" describing a school recital, and as a Hungarian Gypsy performing "Those Were the Days."