An emotionally charged tale of a disconnected family whose spirits are rekindled with the help of a friend and a shared love of music. In his private moments, Zach Taylor relives his glory days as jazz trumpeter Pepper Taylor.

4400 centers on the return of 4400 people who, previously presumed dead or reported missing, reappear on Earth. Though they have not aged physically, some of them seem to have deeper alterations ranging from superhuman strength to an unexplained healing touch. A government agency is formed to track the 4400 people after one of them commits a murder.