Facing an existential threat that could bring down the Crime Lab, a brilliant team of forensic investigators must welcome back old friends and deploy new techniques to preserve and serve justice in Sin City.

On the run from a lethal assassin, a wily con artist devises a scheme to hide out inside a small-town police station. However, when the hit man turns up at the precinct, an unsuspecting rookie cop finds herself caught in the crosshairs.

A locally born and bred S.W.A.T. lieutenant is torn between loyalty to the streets and duty to his fellow officers when he's tasked to run a highly-trained unit that's the last stop for solving crimes in Los Angeles.

Dr. Temperance Brennan and her colleagues at the Jeffersonian's Medico-Legal Lab assist Special Agent Seeley Booth with murder investigations when the remains are so badly decomposed, burned or destroyed that the standard identification methods are useless.

Deputy Police Chief Brenda Leigh Johnson transfers from Atlanta to LA to head up a special unit of the LAPD that handles sensitive, high-profile murder cases. Johnson's quirky personality and hard-nosed approach often rubs her colleagues the wrong way, but her reputation as one of the world's best interrogator eventually wins over even her toughest critics.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.

A Las Vegas team of forensic investigators are trained to solve criminal cases by scouring the crime scene, collecting irrefutable evidence and finding the missing pieces that solve the mystery.