When a young American woman is sent to Rome to begin a life of service to the church, she encounters a darkness that causes her to question her own faith and uncovers a terrifying conspiracy that hopes to bring about the birth of evil incarnate.

In a dystopian future in which emotions and bodies are regulated by an authoritarian system, an application picks Didi and Ermes to celebrate a mating rite in a nightclub, a place that is now exclusively dedicated to the reproduction of the species. Sylvester, queen / tyrant of the club and some other grotesque beings that inhabit the club lead Didi and Ermes into this rite.