The show is highly topical, given the slowly building #MeToo movement in China. This is being fuelled by numerous instances of sexual discrimination, sexual assault and outright violence towards women, many instances of which have gone viral on Chinese social media before being deleted by censors.

Ruan Liu Zheng returns to her hometown after seven years, and becomes a neurosurgeon at Bei Ya Hospital. However, she did not expect to meet her ex-husband, Ning Zhi Qian, who is the most experienced neurosurgeon at Bei Ya Hospital. Ning Zhi Qian volunteers to be Ruan Liu Zheng's mentor, in order to make up for the hurt he caused her. Ruan Liu Zheng is no longer the weak and timid girl, and shows resolute and determination in both her work and relationship. During work, Ruan Liu Zheng clashes with Ning Zhi Qian, but also works alongside him to save lives. When they were in Africa to execute medical relief efforts, Ning Zhi Qian was injured while saving a patient. Ruan Liu Zheng did not leave his side, and fought hard to save him from the brink of death. Over time, the two gain a new understanding of life, and begin a new relationship.

Zhao Pan'er is a smart and savvy teahouse owner in Qiantang, living alongside her two best friends Sun Sanniang and Song Yinzhang. When she finds out her fiancé left her for another woman of a high ranking officer after becoming an official in the capital of Bianjing, she refuses to give into her fate and decides to travel to the capital in search for the truth. On her way there, she crosses paths with both of her best friends whose lives she saves, and they follow her onward. Gu Qianfan is a commander in an elite capital squadron nicknamed "Living Devil". He is setup by the very people he swears allegiance to and must find out the truth behind a nefarious scheme involving the imperial court. When he first meets Zhao Pan'er, they don't see eye to eye, however this intelligent businesswoman has caught his attention and as they help each other, they get closer to their own goals.

The killers Ge and Song execute daily killing missions for their "Father" organization, and at the same time, Ge is often awakened by fragments of memories in his head during sleep. During a chase, a déjà vu scene causes Ge Jun's brain to fluctuate, and he realizes that these memory fragments have a significant connection to his past. Ge begins to trace his identity, but Song is also involved accidentally. The two of them realize the true nature of the "Father" organization and discover the truth about the evil "memory transplant" being carried out by the organization.