Elle wants to be a singer/songwriter, but her dreams are cut short by the sudden death of her parents. She moves in with her adoptive uncle, who runs a small independent record label whose biggest act, Sensation, is also Elle's biggest pain.

Five years after they defeated Gozer, the Ghostbusters are out of business. When Dana begins to have ghost problems again, the boys come out of retirement to aid her and hopefully save New York City from a new paranormal threat.

God has had just about enough of the human's attitude so he will destroy the planet very soon. It is up to a struggling inventor and a bank teller, both with very amateur criminal minds, to save the world.