The lives and internal power struggles of a powerful and wealthy Cuban-American family running an immensely successful rum and sugar cane business in South Florida.

In Game of LIfe, a children's soccer team is the common link for a multi-layered story giving a candid look into the intersecting lives of five families living in Los Angeles. Game of LIfe examines the complexities of racial and class divisions, and reveals that despite the fragile volatility of human relationships, family is what holds us together and unites us all.

Dr. Temperance Brennan and her colleagues at the Jeffersonian's Medico-Legal Lab assist Special Agent Seeley Booth with murder investigations when the remains are so badly decomposed, burned or destroyed that the standard identification methods are useless.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.