An anthology series following a new medical true crime story each season. Based on the podcast of the same name.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

Ollie, Yeats, and Remy are three unlikely friends who found each other while searching for success, a new start, love, and a place to call home in New York City in 2019.