A woman struck down by terminal cancer shuns conventional medical techniques at her husband's insistence and turns to alternative treatment to combat the disease.

When New York accountant Gilbert Rolfe finds out his mother has a brain tumor, he is devastated. His incorrigible mother, Estelle, has one last wish: to meet the great Greta Garbo. Gilbert, wanting to do this last thing for her, sets out on a wild goose chase through the streets of New York City to track down the iconic star, at the expense of his personal life and much to the chagrin of his wife, Lisa. Can he find Garbo before it's too late?