Follow the lives of a group of young adults living in a brownstone apartment complex on Melrose Place, in Los Angeles, California.

Steve Brooks, a sexist womanizer, is killed by a group of his angry former lovers. In heaven, he makes a bargain with God for redemption and agrees to return to Earth. Once there, he must have a sincere relationship with a female and make her fall in love with him. If not, Steve's soul will become the property of the devil. But the devil hedges his bet, and Steve is reincarnated as a woman named Amanda Brooks.

The Hendersons, an upwardly mobile Seattle family, bring home what they believe to be a dead Bigfoot. But he has only been wounded by a hunter, and the Hendersons offer the creature who they come to call Harry a temporary home until a recovers his health.

Al Bundy is an unsuccessful middle aged shoe salesman with a miserable life and an equally dysfunctional family. He hates his job, his wife is lazy, his son is dysfunctional (especially with women), and his daughter is dim-witted and promiscuous.