Polly Shannon takes a job as a maid to earn money to go to Paris and study opera. She becomes embroiled in a scheme by her two employers to help their friend in the love of a woman who does not fancy him: She will pretend to be interested in their friend instead. The film has been lost.

Kate Tarleton grows up on a Southern plantation and becomes engaged to her guardian, Dr. Robert Manning, a famous surgeon. When Robert, Kate, and her younger sister Mary Lou visit New York, where the doctor wishes to conduct medical experiments, the superstitious Kate goes to the home of a fortune-teller named Stella Hill. Stella, whose principal business is white slave trafficking, drugs Kate and forces her to work in a "den of vice," run by Stella and her accomplice Jimmy Bristol, where she contracts syphilis and goes insane. Robert, Detective Ellis, and a lawyer named Billy Meredith rescue Kate, who recovers her sanity but remembers nothing of her bondage.

Overcome with guilt after having an affair with her best friends husband, Clorinda hopes to escape her past by moving to Europe, where she meets Malcolm, a decent man who falls in love with her.

Young Jim takes over from his father, political boss Jim Gordon Sr. As ruthless and unfeeling as his dad, Young Jim blocks the efforts by a crusading newspaper to bring about reforms in the city's tenement district. But he comes to regret his intransigence when his father is ruined financially.