A Time Prophet predicted that Kai would be the one to destroy the divine order in the league of the 20,000 planets, someday that will happen, but not today. Today a cowardly security guard, an undead assassin, a female with a body designed for sex and a robot head madly in love with her all make up the crew of the spaceship Lexx, the most powerful weapon in the two universes.

Fugitive security guard Stanley Tweedle, love slave Zev Bellringer, and love slave robot head 790 are thrown together by fate and on the run from His Divine Shadow after stealing The Lexx: the most powerful destructive force in two universes.