Dr. Bock, the chief of medicine at a Manhattan hospital, is suicidal after the collapse of his personal life. When an intern is found dead in a hospital bed, it appears to Bock to be a case of unforgivable malpractice. Hours later, another doctor, who happens to be responsible for another case of malpractice, is found dead. Despondent, Bock finds himself drawn to Barbara, the daughter of a comatose missionary.

Two rich American young adults who meet and fall in love in Venice, Italy. With plenty of money and no real responsibilities or direction in life, the couple begin experimenting with illicit drugs. The movie travels through a series of flashbacks showing their progression from marijuana to harder drugs as a result of their complex romantic entanglement with each other.