Can you tell the difference between fact and fiction? Several stories of strange, mysterious and incredible occurrences are chronicled during each episode. It is up to the viewer to decide which stories actually happened and which were completely fabricated by the show’s writers. The answer is revealed by Jonathan Frakes at the conclusion of each episode.

MacShayne is a gambler and small time con-man. After serving a short stretch in jail, he goes to Las Vegas to see his son, but when he gets there, his ex-wife is no longer where she use to live and work and left no forwarding address. Leggett, a recently retired cop, approaches him and tells him that he will help him find his son, if he does something for him. It seems that he is planning to rob a hotel casino and he needs three guys to pull it off. Now two of the guys he recruited has agreed to it but the third is uncertain, so he sets up a poker game wherein MacShayne is suppose to clean him out thus giving Leggett some leverage on him. After doing that he discovers that Leggett is duplicitous and is going stab everybody in the back. So he decides to turn the tables on him.

The new DA of a small town is given the job of prosecuting the alleged murderer of a stripper. Unfortunately, his own father is in charge of the defense. To make matters worse, both attorneys are in love with the wife of the accused.

In cases ripped from the headlines, police investigate serious and often deadly crimes, weighing the evidence and questioning the suspects until someone is taken into custody. The district attorney's office then builds a case to convict the perpetrator by proving the person guilty beyond a reasonable doubt. Working together, these expert teams navigate all sides of the complex criminal justice system to make New York a safer place.

Columbo is a friendly, verbose, disheveled-looking police detective who is consistently underestimated by his suspects. Despite his unprepossessing appearance and apparent absentmindedness, he shrewdly solves all of his cases and secures all evidence needed for indictment. His formidable eye for detail and meticulously dedicated approach often become clear to the killer only late in the storyline.