Seeking to raise his credibility as an actor and to land a role as a tough cop on a new show, Hollywood action star Nick Lang works a deal with New York City Police Capt. Brix, who by chance is one of his fans. Nick will be paired with detective Lt. John Moss and learn how to act like a real cop. But when Nick drives John crazy with questions and imitating him, he gets in the way of John's pursuit of a serial killer.

Having lost their status and credibility five years after covering New York City with gooey roasted marshmallows in Ghostbusters (1984), the city's former heroes and once-popular spirit-hunters struggle to keep afloat, forced to work odd jobs. However, when Dana and her baby have yet another terrifying encounter with the paranormal, it is up to Peter Venkman and his fearless team of supernatural crime fighters to step up and save the day. Once more, humankind is in danger, as rivers of slimy psycho-reactive ectoplasm, paired with the dreadful manifestation of evil sixteenth-century tyrant Vigo the Carpathian, threaten to plunge the entire city into darkness. Is the world ready to believe? Can the Ghostbusters save us for the second time?