Katelyn and Kelsey Winters, two sisters distracted by an argument, unknowingly travel through a stretch of isolated wilderness plagued by mysterious disappearances.

A secret military experiment goes awry, leaking a devastating contaminant in to the air and water. 72 years later: "The Sickness" has forced the unaffected to take shelter in secure compounds.

While on a long journey north, a post-apocalyptic survivor is awakened to the sound of an explosion, and upon investigation, finds the hope that she might not be alone in this deadened world.