Violinist Sydney Wells was accidentally blinded by her sister Helen when she was five years old. She submits to a cornea transplantation, and while recovering from the operation, she realizes that she is seeing dead people.

Llewelyn Moss stumbles upon dead bodies, $2 million and a hoard of heroin in a Texas desert, but methodical killer Anton Chigurh comes looking for it, with local sheriff Ed Tom Bell hot on his trail. The roles of prey and predator blur as the violent pursuit of money and justice collide.