It’s 1958 Manhattan and Miriam “Midge” Maisel has everything she’s ever wanted - the perfect husband, kids, and Upper West Side apartment. But when her life suddenly takes a turn and Midge must start over, she discovers a previously unknown talent - one that will take her all the way from the comedy clubs of Greenwich Village to a spot on Johnny Carson’s couch.

James Carlisle is a successful architect who sees his children every weekend following his divorce from Lyn. When Lyn falls in love with the unstable Bernard, James is forced to take drastic action.