The son of an American mine owner, traveling under the name of Charles Conant, tries to enter England in 1916 after masquerading as a muleteer, but the captain of his ship, suspicious when he sees Charles look through a spyglass, plans to take him back to the United States. Charles escapes and visits his relative, Lady Dartridge, where he falls in love with her daughter, Lady Joan Templar, who is loved by her cousin, the chief constable, George Templar. Templar, suspicious of Charles' manner and unexplainable meetings and activities, wants to arrest him as a spy.

Adapted from a novel by Larry Evans, Once to Every Man tells the tales of Danny Bolton, a pugnacious, hard-drinking country boy.