On a small island in the Florida Everglades, a DEA agent and a local sheriff gather a team of locals to take down a giant meth-fueled alligator.

On a trip to Colombia, a group of college students encounter a fifty-foot boa constrictor, hungry for blood.

After a family tragedy, Chuck Wilson hopes to start a new life in Ashland Falls with his wife Maria and little sister Elizabeth, but he quickly discovers that the town has a dark secret.