During the summer of 1981, a group of friends in New York are completely unprepared for the onslaught of AIDS. What starts as a rumor about a mysterious "gay cancer" soon turns into a major crisis as, one by one, some of the friends begin to fall ill, leaving the others to panic about who will be next. As death takes its toll, the lives of these friends are forever redefined by an unconditional display of love, hope and courage.

A gallery of characters in Brooklyn in the 1950s are crushed by their surroundings and selves: a union strike leader discovers he is gay; a prostitute falls in love with one of her clients; a family cannot cope with the fact that their daughter is illegitimately pregnant.