Three hit people - two men, one woman, who have never met before are placed on a road trip down the East Coast together. The only thing they have in common is that they have all worked for the same boss - and, as they swap stories, discover that they have all screwed up for this same boss in the past. As they share their stories of errors on the job - seen through visual, stirring flashbacks - they begin to wonder why it was they were put together in the first place and what might be waiting for them at the end of their little road trip.

Jerri Blank is a former prostitute and junkie whore who returns to high school as a 46-year-old freshman at Flatpoint High. Jerri ran away from home and became 'a boozer, a user, and a loser' after dropping out as a teenager, supporting her drug habits through prostitution, stripping, and larceny. She has been to prison several times, the last time because she 'stole the TV'. At home, Jerri's father Guy is comatose, although he seems perfectly capable of amazing feats. Her stepmother Sara is vain and bitter, and stepbrother Derrick is a bullying jock. Jerri tries to do things the right way but always ends up learning the wrong lesson. Her hijinks often involve, either directly or indirectly, neurotic history teacher Chuck Noblet and his secret lover, sensitive art teacher Geoffrey Jellineck.