In post-war Germany, liberation by the Allies does not mean freedom for everyone. Hans Hoffmann is repeatedly imprisoned under Paragraph 175, which criminalizes homosexuality. Nevertheless, over the decades, he continues his quest for freedom and love, even if he finds it in the most unusual places.

400 years into the future, disease has wiped out the majority of the world's population, except one walled city, Bregna, ruled by a congress of scientists. When Æon Flux, the top operative in the underground 'Monican' rebellion, is sent on a mission to kill a government leader, she uncovers a world of secrets.