Frankie gets the chance to leave her foster care home to attend an exclusive Swiss boarding school. However, the opportunity of a lifetime comes at a deadly price when one of her classmates is murdered and everyone is quick to blame her.

Dr. Bashir Hamed, a Syrian doctor with battle-tested skills in emergency medicine, makes the difficult decision to flee his country and build a new life in Canada with his younger sister Amira. Bash works to navigate a new environment after earning a coveted residency in the Emergency Department of one of the best hospitals in Toronto, York Memorial.

Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join a prestigious hospital's surgical unit. Unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.