London, one year from today... The dogs of England are dying, of "Mad Dog Disease," and Rabbie Burns, young drifter and certified schizophrenic, is hearing voices again - on Underground trains, over supermarket tannoys, and on his own T.V. He has 30 hours, a last weekend, to save the world from itself, before the "Supreme Being" himself loses patience and starts over, with a new species...

Set during the 1960s in the fictional North Yorkshire village of Aidensfield, this enduringly popular series interweaves crime and medical storylines.