Music Pictures gives us four legacy portraits of New Orleans music figures Irma Thomas, Little Freddie King, Ellis Marsalis, and The Tremé Brass Band. Now in their 80s, these local masters continue their practice, for the love of the music, in the city that made them who they are.

After his daughter persuades him to move into a new apartment, aged widower Fred strikes up a friendship with his eccentric 74-year-old neighbour Elsa, who convinces him it's never too late to keep enjoying life. Although he seemed resigned to a miserable bedridden existence, Fred embraces Elsa's youthful enthusiasm as she introduces him to the path of life and entertains him with outlandish stories about her past life. But when he discovers Elsa's terminally ill, Fred decides to accompany her on the trip of her dreams to the eternal city of Rome to help her fulfil a lifelong ambition.