Manna From Heaven is a comedic fable about what happens when you get a gift from God (a financial windfall), but many years later you find out it was a just a loan and it's due immediately. Once upon a time, many years ago, a neighborhood in Buffalo, NY is mysteriously showered with 20 dollar bills. Theresa, a young girl who everyone thinks is a saint, doesn't have much trouble convincing her loose-knit "family" that the money is a gift from Heaven. Years later, Theresa, who has become a nun, has an epiphany that it is time to pay the money back, so she calls the eccentric group together to repay the "loan." The problem is, nobody wants to give back the money, nobody has the money, they don't know to whom it belongs, and most of them can't stand each other. Along the way, the characters learn about family, romance, reconciliation and redemption, and by working together they begin to realize their full potential.

Jerri Blank is a former prostitute and junkie whore who returns to high school as a 46-year-old freshman at Flatpoint High. Jerri ran away from home and became 'a boozer, a user, and a loser' after dropping out as a teenager, supporting her drug habits through prostitution, stripping, and larceny. She has been to prison several times, the last time because she 'stole the TV'. At home, Jerri's father Guy is comatose, although he seems perfectly capable of amazing feats. Her stepmother Sara is vain and bitter, and stepbrother Derrick is a bullying jock. Jerri tries to do things the right way but always ends up learning the wrong lesson. Her hijinks often involve, either directly or indirectly, neurotic history teacher Chuck Noblet and his secret lover, sensitive art teacher Geoffrey Jellineck.