Mad scientist Prospero runs away with his blind daughter Miranda to Tromaville, hiding from evil pharmaceutical execs, including his own sister Antoinette who ruined his career after he found the cure against opioid addiction. With the help of a handicapped crack-whore, he releases a massive amount of laxative to whales, while his enemies are on a cruise ship to North Korea. A humongous shitstorm washes the boat away and brings them to Tromaville, where Prospero can now fully realize his ultimate vengeance.

A giant lizard terrorizes a rural mid west community with a group of heroic young people led by Chase Winstead attempting to destroy the creature.

A reporter follows an incestuous brother and sister who kill tourists in the name of God.