Follows a criminal gang in Rome that has a near monopoly of the city's heroin trade. Besides their internal feuding, the gang has to deal with the Camorra and Sicilian Mafia that both supply its heroin, the police led by Commissioner Scialoja and the Italian secret services.

Stefano, a philosophy grad student without a future, tries to commit suicide after his girlfriend leaves him. He is saved by Giulio, a wisecracking plumber who takes him home and teaches him the tricks of the trade. When Lucia, a woman disappointed in both men and conventional jobs who has started to work as a prostitute, calls them to repair a sink, for Stefano it's love at first sight.

Dive into the Eternal City – see Rome like you’ve never seen it before. Storefront robberies, bizarre murders, career dreamers, and cameos from Italy's foremost directors and actors feature in this star-studded omnibus tale about life and love.

An epileptic 12-year-old girl, Pippi, is hospitalized in the psychiatric ward instead of the neurological ward, due to an administration error. Out of this mistake begins the difficult journey towards being cured.