Nell Serrano is a broke and newly single self-described disaster. She works to restart the life and career she left behind some 10 years ago. When writing obituaries is the only job she can find, Nell starts getting life advice from an unlikely (and dead) source.

With his family away, a devoted stay-at-home dad enjoys his first me time in years by joining his hard-partying old friend on a wild birthday adventure.

Vince, a charismatic gym owner with no ambition lives with his younger brother Michael, a gorgeous idiot. Their simple life of women and working out is put on hold when the teenage son of Vince is dropped off on their doorstep by Priya, one of his old high school flings.

The rivalries, romances, hopes and fears of the residents of the fictional Midwestern metropolis, Genoa City. The lives and loves of a wide variety of characters mingle through the generations, dominated by the Newman, Abbott, Baldwin and Winters families.