Clawdeen Wolf, half human and half werewolf, has recently started attending Monster High, a school for monsters in all forms. After quickly befriending her classmates Frankie Stein and Draculaura, Clawdeen feels like she has finally found a place where she can truly be herself, or so she thinks. Soon, a devious plan to destroy Monster High threatens to reveal her real identity and Clawdeen must learn to embrace her true monster heart before it's too late.

Honor is an ambitious high school senior whose sole focus is getting into Harvard, assuming she can first score the coveted recommendation from her guidance counselor, Mr. Calvin. Willing to do whatever it takes, Honor concocts a Machiavellian-like plan to take down her top three student competitors, until things take a turn when she unexpectedly falls for her biggest competition, Michael.