Siblings Gretel and Kevin are to be bestowed super powers by space aliens on their birthdays, but after Kevin's powers accidentally go into Hamster, his pet hamster instead, they form the duo of "Hamster & Gretel". Now Kevin must figure out how to work with both Gretel and Hamster to protect their city from mysterious dangers.

The series consists of theme songs to various Disney Channel shows, redone by a supporting character of that series.