Uh-Oh! is the story of Jonny, a silly, good-hearted, bumbling man with an uncommon streak of bad luck, until he meets a sea captain. He goes through several jobs and sets of circumstances where he inevitably messes up, thus revealing the meaning of the film title - he spends most of his time saying "uh oh!" as he watches fiasco after fiasco unfurl, with him as the catalyst.

Four Harlem friends -- Bishop, Q, Steel and Raheem -- dabble in petty crime, but they decide to go big by knocking off a convenience store. Bishop, the magnetic leader of the group, has the gun. But Q has different aspirations. He wants to be a DJ and happens to have a gig the night of the robbery. Unfortunately for him, Bishop isn't willing to take no for answer in a game where everything's for keeps.