Uh-Oh! is the story of Jonny, a silly, good-hearted, bumbling man with an uncommon streak of bad luck, until he meets a sea captain. He goes through several jobs and sets of circumstances where he inevitably messes up, thus revealing the meaning of the film title - he spends most of his time saying "uh oh!" as he watches fiasco after fiasco unfurl, with him as the catalyst.

Madsen, a bounty hunter with a bad liver and an even worse attitude, with the help of the lovely Dr. Forster, must stop Dr. Oh and Takeru and restore order to the world.