Jack Sadelstein, a successful advertising executive in Los Angeles with a beautiful wife and kids, dreads one event each year: the Thanksgiving visit of his twin sister Jill. Jill's neediness and passive-aggressiveness is maddening to Jack, turning his normally tranquil life upside down.

During a Day of the Dead celebration, the dead come to life to prey upon the living. In the remote Mexican village of Santa Bonita, a nightmare lay buried for over a century. But when a group of hard-partying students from the OC are stranded in this strange town, they discover an innkeeper with a dark secret a sheriff with a shocking past and a holiday that demands the most horrific sacrifice of all. Now the ceremony can commence. The hordes of the undead have been unleashed. And on this day, an unstoppable feast of human flesh has begun!