In the land of Duffyville, Jim Duffy is the unquestioned battle master. While in the process of training his younger brother Slim to become his successor, his title is challenged by local scoundrel J.T. Smash.

Mad scientist Prospero runs away with his blind daughter Miranda to Tromaville, hiding from evil pharmaceutical execs, including his own sister Antoinette who ruined his career after he found the cure against opioid addiction. With the help of a handicapped crack-whore, he releases a massive amount of laxative to whales, while his enemies are on a cruise ship to North Korea. A humongous shitstorm washes the boat away and brings them to Tromaville, where Prospero can now fully realize his ultimate vengeance.

A struggling drug addict is plunged into a tortured netherworld, where he must defend his spirit from a ravenous horde of soul-addicted junkies.