Mili watched in horror as her mother was murdered, becoming another MMIW statistic. Now 17, Mili’s former crew kidnaps her girlfriend. Tribal cops and an agent from the Federal Missing and Murdered Unit are on the case, but Mili waited for the authorities once…she won’t wait this time.

After an evening of drinking, six men find themselves in front of The God of the Joke. Distressed to find that people aren't laughing anymore, He gives the six friends a mission: to save the world with the Eleven Commandments of the Joke. The men enthusiastically take on their task. They undertake various tests aimed at pushing the limits of stupidity.