Natalie and Joshua appear to be the picture-perfect couple, but looks can be deceiving. When Natalie discovers her husband has led a secret life, she is forced to deal with losing everything she loves. Newly divorced and soured on relationships, Natalie is picking up the pieces of her shattered world. In the process of healing, she meets a new man who challenges the boundaries of her trust and her ability to fall in love again.

William Masters and Virginia Johnson are real-life pioneers of the science of human sexuality. Their research touched off the sexual revolution and took them from a midwestern teaching hospital to the cover of Time magazine and multiple appearances on Johnny Carson's couch. He is a brilliant scientist out of touch with his own feelings, and she is a single working mother ahead of her time. The series chronicles their unusual lives, romance, and unlikely pop culture trajectory.