William Masters and Virginia Johnson are real-life pioneers of the science of human sexuality. Their research touched off the sexual revolution and took them from a midwestern teaching hospital to the cover of Time magazine and multiple appearances on Johnny Carson's couch. He is a brilliant scientist out of touch with his own feelings, and she is a single working mother ahead of her time. The series chronicles their unusual lives, romance, and unlikely pop culture trajectory.

Straitlaced Princeton University admissions officer, Portia Nathan is caught off-guard when she makes a recruiting visit to an alternative high school overseen by her former college classmate, the freewheeling John Pressman. Pressman has surmised that Jeremiah, his gifted yet very unconventional student, might well be the son that Portia secretly gave up for adoption many years ago.

Thanks to a Japanese scientist's invention of synthetic, blood vampires have progressed from legendary monsters to fellow citizens overnight. And while humans have been safely removed from the menu, many remain apprehensive about these creatures "coming out of the coffin." Religious leaders, government officials, and vampire fundamentalists around the world have chosen their sides, but in the small Louisiana town of Bon Temps, the jury is still out.

Young, innocent, and quirky June (Felicia Day), a violinist, spends her days working in an oddball Venice coffee shop, her nights rehearsing for a professional music career, and all-hours daydreaming about the beautiful man that's destined just for her. When she actually meets him in her own apartment building, she finds out Jack (Chris Henry Coffey) is engaged to the quintessential gorgeous bitch, Quinn (Cindy Dolenc). The conflict ensues and the romance is tested. Whether it's indulging her loony Grandma (Ellen Geer) through rehearsals of her own funeral, or dealing with the overzealous video-store manager (Ted Michaels) and his crush, June stumbles through her potential love life, her best friend Mary at her side.