Two potheads battle a neighboring cookie magnate and enlist the help of a charming porn star to help them navigate the ups and downs of managing a small business in their quest for profits and the perfect bud.

William Masters and Virginia Johnson are real-life pioneers of the science of human sexuality. Their research touched off the sexual revolution and took them from a midwestern teaching hospital to the cover of Time magazine and multiple appearances on Johnny Carson's couch. He is a brilliant scientist out of touch with his own feelings, and she is a single working mother ahead of her time. The series chronicles their unusual lives, romance, and unlikely pop culture trajectory.