Two musicians are unknowingly drawn into a supernatural scheme.

After Faye and her psychotic boyfriend, Vince, successfully rob a mob courier, Faye decides to abscond with the loot. She heads to Reno, where she hires feckless private investigator Jack Andrews to help fake her death. He pulls the scheme off and sets up Faye with a new identity, only to have her skip out on him without paying. Jack follows her to Vegas and learns he's not the only one after her. Vince has discovered that she's still alive.

When car dealer Charlie Babbitt learns that his estranged father has died, he returns home to Cincinnati, where he discovers that he has a savant older brother named Raymond and that his father's $3 million fortune is being left to the mental institution in which Raymond lives. Motivated by his father's money, Charlie checks Raymond out of the facility in order to return with him to Los Angeles. The brothers' cross-country trip ends up changing both their lives.