Hunter, a bride-to-be, feels overworked and unappreciated. Her artistic spirit is squelched by the shallow corporate world she’s in and she has had enough. Unfortunately, she feels as if she can’t turn to Ian, her commercial executive fiancé, for solace. As her wedding day approaches, Hunter and her three bridesmaids embark on a road trip to Las Vegas for one last hoorah together. As the girls venture from the city, they decompress and let their personal barriers fall. An impromptu sightseeing excursion into the desert leads to a clash of anxieties and attitudes between Hunter, the bridesmaids, and her fiancé as Hunter searches for the road that’s right for her.

Melvin Udall, a cranky, bigoted, obsessive-compulsive writer of romantic fiction, is rude to everyone he meets, including his gay neighbor, Simon. After Simon is hospitalized, Melvin finds his life turned upside down when he has to look after Simon's dog. In addition, Carol, the only waitress at the local diner who will tolerate him, must leave work to care for her sick son, making it impossible for Melvin to eat breakfast.

A middle-aged fisherman and a young college co-ed fall in love with each other.