Neale and Pedro fly cargo between Chungking and Calcutta. When their buddy Bill is murdered they investigate. Neale meets Bill's fiancée Virginia and becomes suspicious of a deeper plot while also falling for her charms.

Lotus Long plays the title role, an American-educated Japanese woman broadcasting enemy propaganda to American troops. Captured GI Pete Sherman is one of a group of POWS slated to be interviewed on Tokyo Rose's radio program. Instead of advising his comrades to surrender (as ordered), Sherman uses his innate Yankee knowhow to hoist the treacherous deejay on her own petard. Managing to make his escape, Sherman hooks up with the Japanese Underground, convincing anti-militarist Charlie Otani to aid in a kidnapping plot aimed at Tokyo Rose.