Adrian Monk was once a rising star with the San Francisco Police Department, legendary for using unconventional means to solve the department's most baffling cases. But after the tragic (and still unsolved) murder of his wife Trudy, he developed an extreme case of obsessive-compulsive disorder. Now working as a private consultant, Monk continues to investigate cases in the most unconventional ways.

After being duped and going bankrupt, model Maddie is convinced by David to become a partner in a detective agency. Together they solve various cases, while getting comfortable with each other.

A San Antonio cop, as an act of faith, vows to run more than 300 miles in five days, hoping his critically ill five-year-old daughter will survive to greet him at the finish.