Six friends on a road trip stop for the night at a bed and breakfast in the sleepy town of Lovelock. After a night that leaves both the inn's owner and chef dead, the gang finds themselves under suspicion by the local sheriff. But that's only the beginning as nearly all of the town's quirky residents become possessed by an evil spirit and pin down the friends inside the B&B.

ER explores the inner workings of an urban teaching hospital and the critical issues faced by the dedicated physicians and staff of its overburdened emergency room.