Italian police inspector Coliandro — an ignorant, boorish, but fundamentally kind-hearted oaf, whose entire worldview is informed by American cop movies — protects the good citizens of Bologna, routinely saving the day and foiling the plans of evildoers of all sorts by a combination of dumb luck and genuine bravery, while always falling hopelessly in love with the woman at the center of the case.

14-year-old Siddharta, wise beyond his age, has to deal every day with his heroin-addict mother Silvia and an absent father. One day, his four-year-old sister Domitilla accidentally pricks her finger on one of Silvia's used needles without her noticing. Seeking advice on the Internet, Siddharta is told to have her tested for hepatitis and AIDS. Thus he embarks on a odyssey of medical bureaucracy and both kind and uncaring adults.