After the original team developed a top-secret research laboratory to take the shattered ghosts to the next level. But when the discovery of an ancient artifact unleashes an evil force, both new and old must join forces to protect their homeland and save the world from the Second Ice Age... from the very thing that unleashes an unstoppable force from the depths of history. As chaos reigns and pure evil plunges the world into darkness, the Ghostbusters must step forward once again to save humanity from the brink of doom. With two generations of Ghostbusters fighting side by side, the stakes have never been higher. Will they be able to avert the inevitable before everything freezes?

Regina Haywood is the newly promoted deputy inspector of East New York, a working-class neighborhood at the edge of Brooklyn. She leads a diverse group of officers and detectives, some of whom are reluctant to deploy her creative methods of serving and protecting in the midst of social upheaval and the early seeds of gentrification.

The New York office of the FBI brings to bear all their talents, intellect and technical expertise on major cases in order to keep their city and the country safe.

In cases ripped from the headlines, police investigate serious and often deadly crimes, weighing the evidence and questioning the suspects until someone is taken into custody. The district attorney's office then builds a case to convict the perpetrator by proving the person guilty beyond a reasonable doubt. Working together, these expert teams navigate all sides of the complex criminal justice system to make New York a safer place.