Jack Gladney, professor of Hitler studies at The-College-on-the-Hill, husband to Babette, and father to four children/stepchildren, is torn asunder by a chemical spill from a rail car that releases an "Airborne Toxic Event" forcing Jack to confront his biggest fear - his own mortality.

When architect-turned-recluse Bernadette Fox goes missing prior to a family trip to Antarctica, her 15-year-old daughter Bee goes on a quest with Bernadette's husband to find her.