Prohibition-era nightclub crooner Joe E. Lewis has his career and nearly his life cut short when his throat is slashed as payback for leaving the employ of Chicago mob boss Georgie Parker. A broken alcoholic, Joe is brought back from the abyss by his faithful piano player, Austin Mack, who helps turn the former singer into a successful stand-up comedian. But Joe's demons plague his romantic life even as he reaches new heights of success.

Alan Mitchell returns to New York to work for his father Walter, the owner of a fashion house that designs and manufactures dresses. To stay non-union, Walter has hired Artie Ravidge, a hood who uses strong-arm tactics to keep the employees in line.